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KMID : 0379520210370030355
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한국독성학회지
2021 Volume.37 No. 3 p.355 ~ p.367
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Fimbristylis ovata extract and its ability to encounter AGEs-induced neurotoxicity in SH-SY5Y
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Sirirattanakul Suphasarang
Santiyanont Rachana
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Abstract
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Advanced glycation end products (AGEs) upon binding to its receptor (receptor for AGEs, RAGE) trigger several pathological processes involving oxidative stress and inflammatory pathway which play a pivotal role in various degenerative diseases including Alzheimer’s disease. Fimbristylis ovata (F. ovata) has long been reported to be used as a traditional herbal medicine; nonetheless, very few studies have been reported. In this study, the protective effects of F. ovata extract on neurotoxicity of hippocampal neuronal cells (SH-SY5Y) was investigated. When compared to normal control, AGEs treatment significantly induced oxidative stress level and enhanced NF-κB translocation to nucleus in the neuronal cells (p?
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KEYWORD
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Neurotoxicity, Oxidative stress, Pro-inflammatory cytokines, Fimbristylis ovata, SH-SY5Y
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